Letrocord 2.5

Letrocord 2.5

letrozole

Manufacturer:

Intas

Distributor:

Accord Healthcare
Concise Prescribing Info
Contents
Letrozole
Indications/Uses
Adjuvant treatment of postmenopausal women w/ hormone receptor +ve invasive early breast cancer. Extended adjuvant treatment of hormone-dependent invasive breast cancer in postmenopausal women who have received prior standard adjuvant tamoxifen therapy for 5 yr. Neo-adjuvant treatment of postmenopausal women w/ hormone receptor +ve, HER-2 -ve breast cancer. 1st line treatment in postmenopausal women w/ hormone-dependent advanced breast cancer. Advanced breast cancer after relapse or disease progression, in women w/ natural or artificially induced postmenopausal endocrine status who have previously been treated w/ anti-oestrogens. Neo-adjuvant treatment of post-menopausal women w/ hormone receptor -ve HER-2 breast cancer where chemotherapy is not suitable & immediate surgery is not indicated.
Dosage/Direction for Use
Adult & elderly 2.5 mg once daily. In the adjuvant & extended adjuvant setting, treatment should continue for 5 yr or until tumour relapse occurs, whichever is first. In the adjuvant setting, a sequential treatment schedule (2 yr letrozole followed by tamoxifen 3 yr) could also be considered. In the neoadjuvant setting, treatment w/ could be continued for 4-8 mth in order to establish optimal tumour reduction.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Premenopausal endocrine status. Pregnancy. Breastfeeding.
Special Precautions
Measure luteinising hormone, FSH & oestradiol levels prior initiation in patients whose menopausal status is unclear. Assess bone mineral density to women w/ history of osteoporosis & or fractures, increased risk of osteoporosis prior commencement of adjuvant & extended adjuvant treatment. Initiate treatment or prophylaxis for osteoporosis. Monitor during & following treatment. Minor influence on the ability to drive & use machines. Renal & hepatic impairment. Pregnancy & lactation. Not recommended for childn & adolescents ≥17 yr.
Adverse Reactions
Hypercholesterolaemia; hot flushes. Anorexia, increased appetite; depression; headache, dizziness; HTN.
Drug Interactions
May diminish pharmacological action & decrease plasma conc w/ tamoxifen.
MIMS Class
Cancer Hormone Therapy
ATC Classification
L02BG04 - letrozole ; Belongs to the class of enzyme inhibitors. Used in treatment of neoplastic diseases.
Presentation/Packing
Form
Letrocord 2.5 FC tab 2.5 mg
Packing/Price
30's
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